2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Potassium Channel
  5. Potassium Channel Agonist

Potassium Channel Agonist

Potassium Channel Agonists (9):

Cat. No. Product Name Effect Purity
  • HY-126653
    Atpenin A5
    		Agonist 99.94%
    Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), and is an effective mKATP channel agonist and cardioprotective agent.
  • HY-101360
    1-EBIO
    		Agonist 99.96%
    1-EBIO is an activator of Ca2+ sensitive K+ channels. 1-EBIO is used to study the role of K+ channels in diverse physiological functions.
  • HY-125469
    ICA-105665
    		Agonist 99.75%
    ICA-105665 (PF-04895162) is a potent and orally active neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels opener. ICA-105665 inhibits liver mitochondrial function and bile salt export protein (BSEP) transport (IC50 of 311 μM). ICA-105665 can penetrate the blood-brain barrier and has antiseizure effects.
  • HY-B1500
    2,2,2-Trichloroethanol
    		Agonist 99.53%
    2,2,2-Trichloroethanol, the active form of Chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4).
  • HY-102070
    NS13001
    		Agonist 99.62%
    NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.
  • HY-100276
    Naminidil
    		Agonist 99.94%
    Naminidil is a cyanoguanidine KATP opener.
  • HY-159506
    Bimokalner
    		Agonist
    Bimokalner (Bimokalnerum) is a voltage-gated potassium channel (Kv7.4) agonist.
  • HY-142723
    KCa2 channel modulator 1
    		Agonist
    KCa2 channel modulator 1 (compound 2o) is a potent subtype-selective positive modulator of KCa2 channel. KCa2 channel modulator 1 potentiates human KCa2.3 channels with an EC50 value of 0.19 μM and 0.99 μM on the rat KCa2.2 channel subtype.
  • HY-118628A
    BML264
    		Agonist
    BML264 ((E)-N-(p-amylcinnamoyl) anthranilic acid) is an agonist for TREK-1. BML264 can be used to study diseases associated with TASK1 dysfunction.